11/24/2017 0 Comments Alli Blog Weight LossOrlistat - Wikipedia. Orlistat. Clinical data. Trade names. Xenical, Alli. AHFS/Drugs. com. Monograph. Medline. Plusa. 60. License data. Pregnancycategory. AU: B1. US: X (Contraindicated)Routes ofadministration. ![]() Oral. ATC code. Legal status. Legal status. Pharmacokinetic data. Bioavailability. Negligible. It is marketed as a prescription drug under the trade name Xenical by Roche in most countries, and is sold over- the- counter as Alli. It is intended for use in conjunction with a healthcare provider- supervised reduced- calorie diet. Pooled data from clinical trials suggest that people given orlistat in addition to lifestyle modifications, such as diet and exercise, lose about 2–3 kilograms (4. In a large randomized controlled trial, orlistat was found to reduce the incidence of diabetes by nearly 4. They decrease with time, however, and are the most frequently reported adverse effects of the drug. Over- the- counter approval was controversial in the United States, with consumer advocacy group Public Citizen repeatedly opposing it on safety and efficacy grounds. In Australia it is listed as an S3 medication and so is available over the counter in pharmacies. The amount of weight loss achieved with orlistat varies. In one- year clinical trials, between 3. Between 1. 6. 4% and 2. ![]() ![]() Oily stools and flatulence can be controlled by reducing the dietary fat content to somewhere in the region of 1. Food and Drug Administration (FDA) approved a revised label for Xenical to include new safety information about cases of severe liver injury that have been reported rarely with the use of this medication. This study showed no evidence of an increased risk of liver injury during treatment. They concluded: The incidence of acute liver injury was higher in the periods both immediately before and immediately after the start of orlistat treatment. This suggests that the observed increased risks of liver injury linked to the start of treatment may reflect changes in health status associated with the decision to begin treatment rather than any causal effect of the drug. ![]() Long- term. In 2. ACF) colon lesions than did the carcinogen plus high- fat chow without orlistat. Alli® is the only FDA-approved over-the-counter weight loss drug. Learn how alli® can be part of your healthy weight loss plan. The best weight loss supplements that work for both men and women. These 2 weight loss supplements are safe, natural & healthy. A Mayo Clinic specialist discusses the effectiveness of Alli, an over-the-counter weight-loss pill. The Anderson Method is the most effective book regarding permanent weight loss. Find rapid weight loss methods that really work in an effective manner and reduce your. ![]() A multivitamin tablet containing vitamins A. When lipase activity is blocked, triglycerides from the diet are not hydrolyzed into absorbable free fatty acids, and instead are excreted unchanged. Only trace amounts of orlistat are absorbed systemically; the primary effect is local lipase inhibition within the GI tract after an oral dose. The primary route of elimination is through the feces. Orlistat was also recently found to inhibit the thioesterase domain of fatty acid synthase (FAS), an enzyme involved in the proliferation of cancer cells but not normal cells. However, potential side effects of Orlistat, such as inhibition of other cellular off- targets or poor bioavailability, might hamper its application as an effective antitumor agent. One profiling study undertook a chemical proteomics approach to look for new cellular targets of orlistat, including its off- targets. ![]() Orlistat also show potential activities mycobacteria and Trypanosoma brucei parasite (See further reading). At the standard prescription dose of 1. In Australia, the European Union. Initially available only with a prescription, it was reclassified as a . In 2. 00. 7 the Committee decided to keep orlistat as a Schedule 3 drug, but withdrew its authorization of direct- to- consumer Xenical advertising, stating this . Food and Drug Administration advisory panel voted 1. OTC formulation of orlistat, to be marketed under the name alli by Glaxo. Smith. Kline. It is sold as 6. Patent and Trademark Office. ![]() Commercial Weight-loss Products and Programs (Weight maintenance, Overweight, Obesity and Severe Obesity) This section reviews some of the most popular types of. Compare prices of XLS-Medical weight loss management supplements. Find the lowest price online with our unique comparison list. Lose 3x the weight & save money. Alli (orlistat) blocks some of the fat that you eat, keeping it from being absorbed by your body. The extension was granted on 2. July 2. 00. 2. In Austria, orlistat is available under the brand name Slimox. In Malaysia, orlistat is available under the brand name Cuvarlix and is marketed by Pharmaniaga. Society and culture. Food and Drug Administration issued an alert stating that some counterfeit versions of Alli sold over the Internet contain no orlistat, and instead contain the weight- loss drug sibutramine. The concentration of sibutramine in these counterfeit products is at least twice the amount recommended for weight loss. J Clin Pharmacol. PMID 8. 62. 68. 84. Australian Journal of Chemistry. Retrieved 1. 3 July 2. Helvetica Chimica Acta. Journal of Organic Chemistry. Padwal RS, ed. Cochrane Database Syst Rev (3): CD0. PMID 1. 52. 66. 51. Diabetes Care. 2. PMID 1. 46. 93. 98. Retrieved 9 June 2. Retrieved 1. 6 March 2. Siebenhofer A, ed. Cochrane Database Syst Rev. CD0. 07. 65. 4. PMID 1. Retrieved 1. 9 February 2. Retrieved 1. 3 July 2. Archived from the original on 2. June 2. 00. 7. Retrieved 2. June 2. 00. 7. Los Angeles Times. Archived from the original on 1. June 2. 00. 7. Retrieved 2. June 2. 00. 7. 7 February 2. Retrieved 8 April 2. Arq Bras Endocrinol Metab. PMID 1. 67. 67. 30. Free full text with registration^. The New York Times. Retrieved 1. 1 December 2. PMID 9. 91. 84. 78. Menendez; L. Lupu (2. Annals of Oncology. PMID 1. 58. 70. 08. Cancer Lett. 2. 40 (2): 2. PMID 1. 63. 77. 08. N Engl J Med. 3. 39 (1. PMID 9. 79. 11. 43. J Clin Pharmacol. PMID 1. 27. 23. 46. March 2. 01. 4. Retrieved 1. November 2. 01. 4. PMID 1. 76. 18. 29. Thomson PDR. ISBN 1- 5. Glaxo. Smith. Kline. Archived from the original on 1. July 2. 00. 7. Retrieved 1. August 2. 00. 7. Retrieved on 2. BBC News Online. 2. January 2. 00. 9. Retrieved 2. 2 January 2. Australian. Therapeutic Goods Administration. February 2. 00. 7. Retrieved 3 March 2. The Washington Post. January 2. 00. 6. Retrieved 1. 0 August 2. Food and Drug Administration (FDA). February 2. 00. 7. Retrieved 7 February 2. The New York Times. Retrieved 1. 0 February 2. Glaxo. Smith. Kline. January 2. 00. 9. Retrieved 2. 2 January 2. United States Patent and Trademark Office. Retrieved 8 April 2. Drug. Patent. Watch. Biotech Blog. 1 June 2. Retrieved 2. 0 June 2. The Deccan Chronicle. Retrieved 2. 6 November 2. The Wall Street Journal. Glaxo said the issue wasn't a lack of interested buyers, but manufacturing problems that have led to shortages of the diet pill and forced the company to delay the product's sale. January 2. 01. 0. Retrieved 2. 4 January 2. Further reading. Journal of Medicinal Chemistry. PMID 8. 30. 88. 67. Hanessian, Stephen; Tehim, Ashok; Chen, Ping (1. The Journal of Organic Chemistry. Peng- Yu, Yang; Kai, Liu; Mun Hong, Ngai; J. Lear, Martin; R. Wenk, Markus; S. Qin, Yao (2. 01. 0). Journal of the American Chemical Society. PMID 2. 00. 28. 02. Peng- Yu, Yang; Min, Wang; Kai, Liu; Mun Hong, Ngai; Omar, Sheriff; J. Lear, Martin; Siu Kwan, Sze; Cynthia Y., He; S. Qin, Yao (2. 01. 2). Chemistry: A European Journal. PMID 2. 26. 74. 87. Alli: Uses, Dosage & Side Effects Information. Generic Name: orlistat (OR li stat)Brand Names: alli, Xenical. What is alli? alli (orlistat) blocks some of the fat that you eat, keeping it from being absorbed by your body. This medicine must be used together with a reduced- calorie diet. Medications distributed from Internet sales may contain dangerous ingredients, or may not be distributed by a licensed pharmacy. Samples of . For more information, contact the U. S. Food and Drug Administration (FDA) or visit www. Important information. Do not take alli if you are pregnant. Weight loss is not recommended during pregnancy, even if you are overweight or obese. You should not take alli if you have gallbladder problems or chronic malabsorption syndrome (an inability to absorb food and nutrients properly). Before taking alli, check with your doctor if you have an underactive thyroid, a history of gallstones or pancreatitis, type 1 or type 2 diabetes, an eating disorder, liver disease, or if you take other weight- loss medications (prescription or over- the- counter). Your daily intake of fat, protein, and carbohydrates should be evenly divided over all of your daily meals. Follow your diet, medication, and exercise routines very closely. Avoid a diet that is high in fat. High- fat meals taken in combination with alli can increase your risk of unpleasant side effects on your stomach or intestines. Before taking this medicine. You should not take alli if you are allergic to orlistat, or if you have: gallbladder problems; chronic malabsorption syndrome (an inability to absorb food and nutrients properly); orif you are pregnant. Ask a doctor or pharmacist if it is safe for you to use alli if you have other medical conditions, especially: liver disease; kidney disease; a history of gallstones or kidney stones; underactive thyroid; a history of pancreatitis; type 1 or type 2 diabetes; an eating disorder (anorexia or bulimia); orif you take any other weight- loss medications (prescription or over- the- counter). Do not use alli if you are pregnant. Weight loss is not recommended during pregnancy, even if you are overweight or obese. Stop taking alli and tell your doctor right away if you become pregnant. Taking alli can make it harder for your body to absorb certain vitamins. These vitamins are important if you are nursing a baby. Do not use this medicine without a doctor's advice if you are breast- feeding a baby. How should I take alli? Take alli exactly as directed on the label. Do not use in larger or smaller amounts or for longer than recommended. Never share alli with another person, especially someone who has a history of eating disorder. Keep the medication in a place where others cannot get to it. This medicine comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions. You may take the medicine either with your meal or up to 1 hour after eating. If you skip a meal or you eat a meal that does not contain any fat, skip your alli dose for that meal. The fat content of your daily diet should not be greater than 3. For example, if you eat 1. Read the label of all food items you consume, paying special attention to the number of servings per container. Your doctor, nutrition counselor, or dietitian can help you develop a healthy eating plan. Your daily intake of fat, protein, and carbohydrates should be evenly divided over all of your daily meals. Follow your diet, medication, and exercise routines very closely. A, D, E, and K. Your doctor may recommend that you take vitamin and mineral supplements while you are taking alli. Follow your doctor's instructions about the type of multi- vitamin or mineral supplement to use. Take your vitamin or supplement at bedtime, or at least 2 hours before or after you take alli. Store at room temperature away from moisture and heat. Keep the bottle tightly closed. Throw away any unused alli after the expiration date on the medicine label has passed. Keep track of the amount of medicine used from each new bottle. Orlistat is a drug that may be misused as a weight- loss aid, and you should be aware if anyone is using your medicine improperly or without a prescription. See also: Dosage Information (in more detail)What happens if I miss a dose? Take the missed dose as soon as you remember, but no more than 1 hour after eating a meal. If it has been more than an hour since your last meal, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1- 8. What should I avoid while taking alli? Avoid a diet that is high in fat. High- fat meals taken in combination with alli can increase your risk of unpleasant side effects on your stomach or intestines. If you also take cyclosporine, do not take it within 3 hours before or 3 hours after you take alli. If you also take levothyroxine (such as Synthroid), do not take it within 4 hours before or 4 hours after you take alli. Get emergency medical help if you have any signs of an allergic reaction to alli: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using alli and call your doctor at once if you have: severe pain in your lower back; blood in your urine, painful or difficult urination; kidney problems- -little or no urinating; swelling in your feet or ankles; feeling tired or short of breath; orliver problems- -nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay- colored stools, jaundice (yellowing of the skin or eyes). Common alli side effects are caused by orlistat's fat- blocking action. These are signs that the medicine is working properly. These side effects are usually temporary and may lessen as you continue using alli: oily or fatty stools; oily spotting in your undergarments; orange or brown colored oil in your stool; gas and oily discharge; loose stools, or an urgent need to go to the bathroom, inability to control bowel movements; an increased number of bowel movements; orstomach pain, nausea, rectal pain. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1- 8. FDA- 1. 08. 8. See also: Side effects (in more detail)What other drugs will affect alli? Tell your doctor about all medicines you use, and those you start or stop using during your treatment with alli, especially: amiodarone; insulin or oral diabetes medicine; seizure medication (especially if your seizures get worse while taking orlistat; a vitamin or mineral supplement that contains beta carotene or vitamin E; orwarfarin (Coumadin, Jantoven). This list is not complete. Other drugs may interact with orlistat, including prescription and over- the- counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. More about Alli (orlistat)Consumer resources. Other brands: Xenical. Professional resources. Related treatment guides. Where can I get more information? Your pharmacist can provide more information about alli. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Copyright 1. 99. 6- 2. Cerner Multum, Inc. Version: 1. 1. 0. Revision Date: 2.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. Archives
November 2017
Categories |